Products

Merxin supplies the drug delivery market with standardised off-the-shelf drug delivery devices.

MRX001 is a "505j" generic multidose blister dry powder inhaler for fluticasone+salmeterol DPI.

MRX002 is a clear PET vial that can be fitted with pMDI valves to visualise formulations and act as a dose indicator.

MRX003 is a "505j" generic capsule capsule inhaler for tiotropium DPI.

MRX003.b & MRX003.c are mouthpiece adaptors to test MRX003 in vitro (NGI) and in vivo (spirometers).

MRX004 is a generic softmist inhaler for tiotropium or/and olodaterol.

 

Product Information

MRX001

MRX001 is a blister based multidose dry powder inhaler (DPI). MRX001 is based on the open-click-inhale-close principle and can be used as a generic device of current branded DPIs.

It is supplied as a pre-assembled device ready to be completed with a blister strip manufactured at the client’s facilities in the country of their choice.

In addition to supplying the pre-assembled device, Merxin can support clients with formulating, testing, manufacturing, and clinical and registration expertise via its partner organisations: Aedestra (www.aedestra.com) and Lustren (www.lustren.com).

MRX001 is available with all the necessary documentation for regulated markets such as EU, US and Japan as well as emerging markets.

MRX001 features:

  • multidose dry powder inhaler
  • blister device (blister not supplied in standard configuration)
  • up to 60 doses
  • dose counter
  • substitutable device: open-click-inhale-close
  • overall dimensions (⌀ 80 mm x l 27 mm)
  • pharmaceutical grade materials for inhalation devices (ABS, POM, PP)
  • customisable colours
  • Merxin’s design

See PDF brochure for more information.

Get in touch with us to receive a full description of MRX001 and terms of access.

MRX001 uses Merxin’s proprietary designs and does not knowingly infringe any IP.

MRX002

MRX002 is a PET vial ideal for modelling pMDI formulations. MRX002 is a clear vial than can be fitted with commercial pMDI valves, continuous and metered.

With MRX002, formulations can be observed and understood in situ. MRX002 is safe to use and a range of solvents compatible with PET. Note however, that MRX002 is not yet pressure rated and is for laboratory use only (i.e. not for clinical use). MRX002 can be used as dose indicator.

In addition to supplying MRX002, Merxin can support clients with formulating, testing, manufacturing, and clinical and registration expertise via its partner organisations: Aedestra (www.aedestra.com) and Lustren (www.lustren.com).

MRX002 features:

  • Clear PET vial to study model pMDI formulations in situ
  • Dimensions:
    • Height L 75 mm
    • Diameter ⌀ 22 mm
    • Crimp diameter ⌀ 20 mm
  • Material: PET (Polyethylene terephthalate)
  • Compatible with HFA solvents, ethanol, water, PEG and glycerol
  • Example of compatible pMDI valves
    • VARI KHFA range
    • Bespak MDI valves
    • Coster MDI valves
  • Ideal for formulation screening
  • For laboratory use only

See PDF brochure for more information.

Get in touch with us to find out about terms of access and prices. Unit prices are quantities dependent and range from GBP 0.25 to 1.

MRX002 uses Merxin’s proprietary designs and does not knowingly infringe any IP.

MRX003

MRX003 is a generic capsule based inhaler for tiotropium DPI.
It is the only "off-the-shelf" commercially available "505j" opportunity for tiotropium DPI in the industry.

MRX003 features:

  • Dimensions: 6.5x7x2.8 cm
  • Materials: ABS and SS
  • Does MRX003 have the same instructions for use as the originator? YES
  • Does MRX003 have the same size and shape factors as the originator? YES
  • Does MRX003 have the same airflow as the originator? YES
  • Does MRX003 have the same NGI profile as the originator? YES
  • Does MRX003 provide an audible feedback like the originator? YES
  • Can I customize MRX003 with my brand ID? YES
  • Can I file a Tiotropium DPI on in-vitro data only in EU with MRX003? YES*
    *you’ll need to get the formulation right though.
     

Pictures are for illustration purposes only.

Get in touch with us to find out about terms of access and prices.

MRX003 uses Merxin’s proprietary designs and does not knowingly infringe any IP.

MRX003.b & MRX003.c

In order to facilitate the testing of formulations with MRX003, Merxin supplies in-vitro and in-vivo adaptors for the NGI/ACI and spirometers. These adaptors can also be used for testing the reference product of tiotropium DPI. MRX003.b has a throat diamater of 36 mm, while MRX003.c has a throat diameter of 28.5 mm. The unit price is GBP 50 when ordering in small quantities.

MRX003.b and MRX003.c uses Merxin’s proprietary designs and do not knowingly infringe any IP.
 

MRX004

MRX004 is a softmist inhaler device. It is a 505j opportunity for tiotropium/olodaterol. MRX004 is also ideal for life cycle management and new molecules.
 
Softmist inhalers are active aqueous devices that create a fine, slow moving aerosol. They accommodate liquid formulations and rely on mechanical energy to create an aerosol. They neither work with propellant nor electric power. They are environmentally friendly and provide a high IP protection.
 
MRX004 also works with new molecules for lung delivery, repurposing of existing molecules, life cycle management, and reformulating molecules from nebulisers or pMDI/DPI.
Get in touch with us to find out about terms of access and prices. If you are looking for a softmist inhaler, be in touch for us to give you the low down: Contact Merxin.
 
MRX004 uses Merxin’s proprietary designs and does not knowingly infringe any IP.